Shkodran Mustafi was an unused substitute v Leicester but is likely to start at Stoke. While the Gunners are coming into the match on the back of an opening day win, Stoke City fell 1-0 to a Wayne Rooney-inspired Everton on the las week.
Hughes remains positive of just what he can bring to a Stoke squad which has seen the likes of Marko Arnautovic and Joselu both move on during the summer. Sunday will come too soon for Alexis Sanchez.
Having joined the Gunners' youth setup in 2001, Wilshere went on his second spell on loan away from the club at Bournemouth last year following an injury plagued season the year before.
The North London side are undefeated in last five meetings with the Potters in all competitions.
There is a school of thought that Giroud no longer has a place at Arsenal following the signing of Alexandre Lacazette, but the imposing forward came through with a late victor again on opening day, and his physicality will benefit the Gunners if this match is to descend into a war of attrition.
Last season, out of top six sides, only Manchester United dropped points at Britannia Stadium.
With a few players returning, there will be changes to the starting lineup of Arsenal. Still it'll be a hard one, because Stoke hate us. And at 18, 19, when we played Fabregas or Nasri they were very young and did not have the experience to deal with that so much. A draw is available at 14/5 odds. This preview is backing 2.5+ goals in the game at 5/6 odds at Betvictor.
When it seemed like Leicester will take three points home, Aaron Ramsey and Olivier Giroud (two assists from Granit Xhaka) saved Arsene Wenger from another big piece of criticism and bought some piece for the French manager. The Wales global, who scored in his substitute against the Foxes, can get you best odds of 4/1 at Bet365.
The only concern is if Stoke keep Arsenal in a fight and don't allow them to settle.