And the elder Curran brother, who made such an impact on debut for England in the Twenty20 series against South Africa earlier this season, is the only real 50-over newcomer as the selectors have chose to wheel out their big guns.
Numerous 13,000 flocking to Emirates Riverside will have been eagerly anticipating witnessing Stokes' renewing T20 hostilities with the man who clubbed him for four huge sixes to win the final in Kolkata last April but he has instead been handed a controversial, but well-earned, breather.
"It's unfortunate it has to be a game at his home ground but we have to stay strong with the decisions and the plans we have so down the line we don't regret playing him in a one-off game".
"Social media won't let me forget it, there's been a few videos going around of late". It was on the stage it was, it was against England and in India. "I'll see what happens".
England, however, have taken the controversial decision to rest him from Saturday's clash.
The sold-out T20 is the first global to be staged at Chester-le-Street since Durham lost the right to host Tests as part of their punishment by the England & Wales Cricket Board for financial problems.
The 26-year-old Brathwaite says its a luxury he is happy to have, "They are all seasoned T20 players and its just for me as a captain to go out there and tell them that whatever they do on the field, they have my full support and whether we win, lose or draw we will re-assess as a team and see how we can continue to improve".
England limited overs captain Eoin Morgan is keen to see how his side fares against an "experienced" West Indies team in Saturday's lone Twenty20 global at Chester-le-Street.
"And if there wasn't an injury risk down the line or a huge Ashes tour coming up potentially he might be able to play".
Rovman Powell (28 off 19) was the only member of the middle order to really get going, with Brathwaite, captaining the Windies in this one-off T20 worldwide, bowled on the sweep.
Morgan insisted England had put their Kolkata hurt behind them, with Stokes and Brathwaite having played a one-day worldwide against each other since their most famous encounter. "It's a quick turnover - we came in yesterday (Tuesday) and we're flying out tomorrow over to Durham", he said. "It's a long time ago".
"As Caribbean players we bring a lot of flair to the game". It's something I'm becoming more relaxed about as I get older'.