CVS, based in Woonsocket, R.I., said the new rules will bring the company in line with prescribing guidelines issued by the Centers for Disease Control and Prevention past year.
According to a release on the CVS Health website, opioid overdose deaths quadrupled from 1999 to 2015.
CVS says it will begin limiting the duration and dose of some prescriptions for opioid painkillers in an effort to combat the growing addiction problem.
An afternoon recap of the day's most important business news, delivered weekdays. "What is more, pharmacy benefit managers are better placed than others in the pharmacy supply chain to put this approach to the CDC guideline into practice", as opposed to medication wholesalers or retail pharmacists.
The retailer announced that it will impose a seven-day limit on the supply of opioids dispensed for certain prescriptions and will also limit the daily dosage of certain opioids.
The company reminded customers pharmacists are available for private consultations, and now it's stepping it up by "strengthening" counseling for those on opioid prescriptions under a "robust safe opioid use education program".
CVS also announced it will install 1,550 in-store disposal units in 750 pharmacies where consumers can drops off unwanted and used medication.
"Prescription and non-prescription opioid misuse is now considered among the most urgent health crises in our country", the company said in a statement.