The 29-year-old Argentine was in involved in the accident in Amsterdam on his day off last month when he had been attending a music concert, and had initially been ruled out for a month.
Guardiola's team, who host Stoke City on Saturday, rounded off their clean sweep in September with a hard fought 1-0 victory at defending champions Chelsea to take their total to 17 goals scored with none conceded during the month.
"When I got to the hospital, I asked the doctor if I could play for City on the Saturday [against Chelsea]".
Aguero, who plays with the 30-year-old in the Argentina setup, believes luring his worldwide colleague to City would be tough as he is more than just another player at Barca.
"I was lucky that I know the agent of Maluma [a Colombian singer], he invited me and I went". I had nearly two days off and going to the airport was when I had that accident.
"But I think Messi, like [Cristiano] Ronaldo, are players who are symbols of their clubs and it's hard for them to leave".