Newcastle United's Spanish midfielder Mikel Merino (L) vies with Liverpool's Senegalese midfielder Sadio Mane (R) during the English Premier League football match between Newcastle United and Liverpool at St James' Park in Newcastle-upon-Tyne, north east England on October 1, 2017.
Senegal, who are top of their World Cup qualifying group, face two crucial games against South Africa on 10 and 14 November, which Mane could miss.
Liverpool struggled without Mane midway through last season, when he was competing at the African Cup of Nations.
He has already missed three domestic matches this season after receiving a suspension following his sending off at Manchester City last month.
The 25-year-old's importance to Liverpool going forward is unquestioned.
"Liverpool especially we talk a lot about (Philippe) Coutinho, Sadio Mane is another one".
For a start, today should be the day Klopp pulls aside Alex Oxlade-Chamberlain and reminds him he is Liverpool's record signing.
The former Red Bull Salzburg man netted 13 goals in 27 Premier League appearances last term, and has scored three in four so far this season.