Hughes, who was a team captain on Never Mind the Buzzcocks on BBC Two, also had his own sitcom, Sean's Show.
Sean Hughes has died at the age of 51.
He died on Monday, his spokesman said.
In 1990, Hughes began earning critical acclaim for his work as he became one of the youngest ever winners of the sought-after Perrier Award.
His death comes just over a week after he told his followers he was in hospital, in a tweet posted on 8 October.
Along with Matt, comedians such as Al Murray and Jason Manford have been paying tribute to Sean since the news of his death broke.
The accolade, now known as the Edinburgh Comedy Awards, is awarded to what is considered the best show of the Fringe Festival in the city.
Describing his fellow comedian as an "icon", Matt was keen to share his condolences before beginning the planned interview, saying as he took to his seat: 'I was very sad to hear that news a few minutes ago'.
The show also played to crowds in London and throughout the UK, Los Angeles, Montreal, Toronto and Australia.
Hughes had a varied career, including a role in hit film The Commitments. A brilliant comic and a lovely bloke.
Hughes had appeared in a few TV shows including Coronation Street, The Last Detective on ITV.