The Belgian midfielder scored the second - a powerful strike that beat Hugo Lloris for pace - as they moved 14 points clear at the top of the Premier League ahead of Manchester United's game at West Bromwich Albion on Sunday.
While he was full of praise for what De Bruyne offers his team with the ball at his feet, Guardiola repeatedly mentioned how significant his contribution was without it, highlighting the influence this will have on some of the club's talented young players. Results such as this one make it incredibly hard to see anyone but City lifting the Premier League trophy in May. Today was a very good example of a team that believe, that have quality and is in very good form.
Alli was only booked for the bad challenge that left De Bruyne in a heap on the ground and struggle to get to his feet.
"This was one of our best performances this season, against a really good opponent that has brilliant players", the Brazil global said.
"We can not assess individual performances after 4-1, I think we need to be calm and talk and next week try to be better. We are busy with the games that we are playing at the moment and mentally we want to keep going and it was a great performance".
"We need to improve, we need to learn from this situation".
The former Barcelona boss now holds records for the longest winning runs in England, Germany and Spain, but has been firm in his belief that City will be unable to match Arsenal's unbeaten Premier League title-winners of 2003-04.