The "Hotline Bling" rapper helped break a record late Wednesday when more than 600,000 people tuned in to watch him play the popular game on Twitch, a streaming service that allows people to watch others play video games.
Later on, the two were also joined by musician Travis Scott and National Football League player JuJu Smith-Schuster.
During play, Drake and Ninja chatted about the benefits of working from home, and whether pineapple pizza is an unholy union or a delicious treat.
The event still fell shy of the overall record for the most people watching a Twitch stream, which is 1.1 million.
It all started with Drake following Ninja on Instagram and the two eventually got into contact with each other about getting some games in on Fortnite. If you're left wondering what this Fortnite Party Royale is and what it has to do with celebrities then say no more, just read on ahead because we're here to explain.
These teams will clash in the premier Fortnite Celebrity Pro-Am in Los Angeles during E3.
Smith-Schuster also shared his excitement on Twitter.
Drake now has more than 36 million followers on the social network.
Ninja by himself is popular enough, especially with his game of choice "Fortnite" now rising up the charts.
"Seeing a top gamer and musician come together on Twitch and unite their large and passionate communities is a cultural moment in terms of building awareness around the appeal of social video and it's only going to grow from here", Kate Jhaveri, Twitch's senior vice president for marketing, said in a statement.
It's been a insane 24 hours for Epic Games and Fortnite.