Though the former Argentina global midfielder's team, which has reached the Champions League final twice and also a semi-final in the last three seasons, start favourites, Simeone knows Marseille's attacking potency could cause the La Liga outfit a serious problem. At odds of [4.0] to score inside 90 minutes, he's worth backing, especially when you consider he takes penalties.
Atletico's build-up to this match has been overshadowed to some extent by constant speculation about his future, with the France striker being tipped to join Barcelona after the World Cup. He will spearhead the attack alongside Diego Costa.
"When I was a youngster I was in the stands experiencing Marseille, so for that reason I wish them all the best for the final". Koke has not been quite the prolific provider of the final pass this season that he has been in the past, but Atletico direct their play through him, and he can launch a counter-attack with devastating efficiency. Les Phocéens ran out comfortable 2-0 victors at the impressive Stade Vélodrome thanks to goals from Florian Thauvin and Clinton Njie.
Asked if his absence will have any impact, he said: "We lived it with Arsenal, at home, when German was [watching] over the team".
Fernando Torres claims that the knowledge of competing with Atletico Madrid in the Europa League final has minimised the feelings of "knowing that my career is over". With the final set for Lyon, Marseille will have to cast aside any demons they have faced in their recent trips up the Rhone.
Boga, who spent this season on-loan at Birmingham City, was born and raised in Marseille before moving to London.
After being held to a goalless draw at Roma in their opening fixture and following that result with a 2-1 home defeat to Chelsea, Atleti's trip to Qarabag was a must-win fixture for Simeone's men.
The French club have previously appeared in four, losing three, the exception being their victory over AC Milan in the inaugural Champions League final in 1993.
Les Olympiens sit fourth in Ligue 1 with just one game left of the season.
OM have been prolific in the Europa League of late, scoring two or more goals in five of their last seven European outings. If you include extra time against Salzburg in the semi, Marseille have scored in each of their last eight games, but have only managed one clean sheet in that time. Full-back Sime Vrsaljko returns from suspension but has competition from the experienced Juanfran for the right-back spot. Centre back Jose Gimenez and midfielder Vitolo are both minor doubts, however.