Giovanni Mannoni, a police commander in Olbia, said the actor did not suffer any serious injuries or break any bones.
The vehicle driver called an ambulance which took Clooney to hospital, AGI added.
Fans were quick to express their relief that the dad-of-two was doing well after the accident, with one tweeting: "I saw George Clooney trending and nearly had a heart attack".
Clooney reportedly was in Sardinia filming a television miniseries adapted from Joseph Heller's World War II novel "Catch-22". Add George Clooney as an interest to stay up to date on the latest George Clooney news, video, and analysis from ABC News.
Daily newspaper La Nuova Sardegna said the 57-year-old Clooney was heading to a film set a auto hit his motorbike.
In the hospital, he was joined by his wife Amal and they left the venue together in a private vehicle. He was reportedly heading to the set when he was struck by the auto.
Clooney is now on the island filming a new TV series "Catch-22", based off the book of the same name written by Joseph Heller.
A photo published on La Nuova Sardegna website shows a black scooter on one side of the road, with a dark blue estate auto facing the other way, at an angle across the central reserve.