The 33-year-old American is best known, of course, for beating Nicolas Mahut 70-68 in the fifth set of an 11-hour, 5-minute match that was contested over three days in Wimbledon's first round in 2010. Federer has opened a chain of Pineapple Pizza bistros, Andy Murray is running for MP.
That was also the last time Nadal made it past the fourth round at the grass-court major; Djokovic, who holds a 26-25 head-to-head lead, beat him in that year's final.
What has impressed us about Anderson, certainly in his match against Gael Monfils was his movement and variety he managed to throw in to get around one of the game's more flamboyant characters.
This feels as much as a lottery as ever, but it just feels like Anderson is ready to prove that his run to the US Open final was no fluke. I really feel for him, because if I had been on the opposite end of this, I don't know how you can take that playing for so long and coming up short.
Wimbledon officials have set the match to re-start at 1pm local time (10pm Saturday night AEST), which is just an hour before Serena Williams aims to equal the Grand Slam wins record in the women's final against Angelique Kerber.
After South African Kevin Anderson's shock Wimbledon win over defending champion Roger Federer on Wednesday, one restaurant chain has noticed a unique public relations opportunity. My feet are sore, they're swollen.
Isner defeated Yannick Maden 6-2 7-6 7-5 to open his tenth Wimbledon. "If one person can't finish the other off before 12-all, then do a tie-breaker there", said Isner. "I think it's long overdue".
He never got a break point in the fifth set. "Because being out there for this length can be pretty damaging from a health standpoint, too".
Hitting with the ferocity and accuracy that made him the most feared player on the planet, the 12-time Grand Slam champion forced Nadal to net to clinch the break, before sealing the set with another cleanly struck victor. After losing the second set, he turned into Vintage Djoker and won 12 of the next 16 games to return to the Wimbledon semis for the seventh time.
Brian Norton was the last South African man to reach the final in 1921.
"John is a great guy and I feel for him", Anderson told the BBC after Friday's match.
Isner then shrugged off needing treatment on a blistered serving hand, found time to usher a ladybird to safety before levelling the match in another tiebreak off his 19th ace.
The almost endless semifinal saga had many arguing for a deciding set tiebreak, from ESPN commentator John McEnroe to Anderson himself. Both Isner and Anderson said they'd like to see that change.
As it became clear that Isner was due for another endless fifth set, tennis fans were far from delighted.
It was the longest match in the history of Centre Court in Wimbledon.
"It gets kind of ridiculous at some point in time when it's over 20-all". "It's pretty tough in the format that we have right now, especially at Slams. They've been watching us for over six hours".