Neil Warnock helped guide Cardiff to the Premier League after finishing runner-up in the Championship last season. Newcastle have been able to add extra firepower in attack this summer, with Yoshinori Muto also in contention, which could be crucial to gaining points in games that they didn't last season.
The Magpies acquitted themselves against Tottenham Hotspur in the season opener but earned no points in a 2-1 loss.
Jan Vertonghen gave Spurs an eighth-minute lead before Joselu restored parity for the hosts just eight minutes later.
Newcastle were finding it hard to get out of their own half and their efforts were hampered further when Hayden was shown a straight red for a tackle from behind on the impressive Murphy.
Newcastle will be without French defender Florian Lejeune for some time following his recent knee surgery but have been boosted with the fitness news of right back DeAndre Yedlin. This match is worth waking up to on Saturday morning for fans in the United States.
With contests, featuring Chelsea, Manchester City, Manchester United and Liverpool, covered individually, let's take a look at the remaining six fixtures of the English Premier league this weekend. Fubo.TV. Sign up for a free seven-day trial here. A win for Newcastle United trades at +140. The Bluebirds have lost 10 of their past 11 against the Magpies dating back to 1981.
Kenedy had an effort saved by Etheridge but Cardiff soon threatened again when Sol Bamba's header from a corner was scrambled clear.
Matt Ritchie probably won't be taken off the field again after a controversial substitution in the opener.
Like many other pundits, he sees it as a crucial match for both sides, despite it coming only a week into the season.