He won three La Liga titles, two Champions Leagues and two Club World Cups during four seasons in charge.
De Bruyne has managed just one appearance so far this season and it now out for three months following a knee injury picked up in training.
The City manager's career in coaching started out with Barcelona's B team.
Meanwhile, NAIJ.com previously had reported that Manchester City star David Silva has hinted he would fancy a move away from the English topflight and join Spanish side Las Palmas in 2020.
De Bruyne's leg brace came off on Monday and now he can begin moving more freely. Then again most just couldn't lose a player of De Bruyne's quality. "I'm sorry, he's not for sale".
The Spaniard went on to praise his midfielder, adding, "De Bruyne does everything and everything well, but still has room to grow".
"Yes. I'm going to coach a national team if I'm given the opportunity and they want me", Guardiola said.
'The other day, I met his parents and you often understand how the children are when you know the parents. Very protected from football. "I do not feel judged by a defeat or victory". We took it on with some incredible players, a young president (Joan Laporta), Txiki (Begiristain).it was a generation of brutal players and the best player in the world (Lionel Messi).
De Bruyne watching on in his knee brace.
The Manchester City playmaker is a key performer in Guardiola's team and stood out last season in the club's Premier League-winning campaign.