"We have shown in the big games that we can compete", said the 25-year-old Denmark attacking midfielder when asked if Spurs lack the right mentality for big-games.
"Now we've shown it's not going to be like that".
Spurs can secure top spot of Group H with a win or, depending on the Real Madrid result, a draw.
Both players missed the worldwide break due to injury, and were not only disappointing against Arsenal, but were both substituted despite Spurs being 2-0 down at the Emirates Stadium.
England defender Danny Rose is in the frame to start, but Pochettino refused to comment on rumours Rose was "fuming" for being left out of Saturday's derby.
However Pochettino says there was nothing untoward about the decision, and speaking after the game insisted both he and Rose agreed it would be better if he trained in the morning rather than play.
If we can take first position and finish on top it is important.
Pochettino said it shows how far Spurs have come in recent seasons that they were heavily criticised after losing to Arsenal. "That is a long-term goal", he said.
Many Arsenal fans have even conceded defeat in their hopes of Ozil and Sanchez staying in North London, suggesting that Arsenal should get some fee by selling them early during the upcoming January transfer window. Okay, we're already in the next stage of the competition but we want to win and try to change the feeling we have from the weekend. The most important thing is the health of the players.